モザイク 破壊 原理。 モザイク

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モザイク 破壊 原理

伊川 正人 (大阪大学微生物病研究所 附属感染動物実験施設) email: 領域融合レビュー, 3, e008 2014 Masahito Ikawa: Genome editing in mice opens a new era for biological and biomedical researches. Gondo, Y. , Fukumura, R. , Murata, T. et al. : ENU-based gene-driven mutagenesis in the mouse: a next-generation gene-targeting system. Exp. Anim. , 59, 537-548 2010 []• Shigeoka, T. , Kawaichi, M. : Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells. Nucleic Acids Res. , 33, e20 2005 []• Kanatsu-Shinohara, M. , Ikawa, M. , Takehashi, M. et al. : Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells. Proc. Natl. Acad. Sci. USA, 103, 8018-8023 2006 []• Austin, C. , Battey, J. , Bradley, A. et al. : The knockout mouse project. Nat. Genet. , 36, 921-924 2004 []• Gaj, T. , Gersbach, C. 3rd. Trends Biotechnol. , 31, 397-405 2013 []• Sakuma, T. , Ochiai, H. , Kaneko, T. et al. : Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity. Sci. Rep. , 3, 3379 2013 []• Cong, L. , Ran, F. , Cox, D. et al. Science, 339, 819-823 2013 []• Mali, P. , Yang, L. , Esvelt, K. et al. : RNA-guided human genome engineering via Cas9. Science, 339, 823-826 2013 []• Wang, H. , Yang, H. , Shivalila, C. et al. Cell, 153, 910-918 2013 []• Mashiko, D. , Fujihara, Y. , Satouh, Y. et al. : Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA. Sci. Rep. , 3, 3355 2013 []• Mashiko, D. , Young, S. , Muto, M. et al. Dev. Growth Differ. , 56, 122-129 2014 []• Yin, H. , Xue, W. , Chen, S. et al. : Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nat. Biotechnol. , 32, 551-553 2014 []• Yang, H. , Wang, H. , Shivalila, C. et al. Cell, 154, 1370-1379 2013 []• Ran, F. , Hsu, P. , Lin, C. et al. : Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell, 154, 1380-1389 2013 []• Qi, L. , Larson, M. , Gilbert, L. et al. : Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell, 152, 1173-1183 2013 []• Perez-Pinera, P. , Kocak, D. , Vockley, C. et al. : RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat. Methods, 10, 973-976 2013 []• Chen, B. , Gilbert, L. , Cimini, B. et al. Cell, 155, 1479-1491 2013 []• Nishimasu, H. , Ran, F. , Hsu, P. et al. : Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell, 156, 935-949 2014 [][]• Kazuki, Y. , Hoshiya, H. , Takiguchi, M. et al. : Refined human artificial chromosome vectors for gene therapy and animal transgenesis. Gene Ther. , 18, 384-393 2011 []• Leeb, M. : Derivation of haploid embryonic stem cells from mouse embryos. Nature, 479, 131-134 2011 [] 参考図書 山本 卓 編 : 今すぐ始めるゲノム編集 実験医学別冊. 羊土社 2014 Yamamoto, T. eds. : Special Issue: Genome Editing. Dev. Growth Differ. , 56, 1-129 2014.

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モザイク 破壊 原理

伊川 正人 (大阪大学微生物病研究所 附属感染動物実験施設) email: 領域融合レビュー, 3, e008 2014 Masahito Ikawa: Genome editing in mice opens a new era for biological and biomedical researches. Gondo, Y. , Fukumura, R. , Murata, T. et al. : ENU-based gene-driven mutagenesis in the mouse: a next-generation gene-targeting system. Exp. Anim. , 59, 537-548 2010 []• Shigeoka, T. , Kawaichi, M. : Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells. Nucleic Acids Res. , 33, e20 2005 []• Kanatsu-Shinohara, M. , Ikawa, M. , Takehashi, M. et al. : Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells. Proc. Natl. Acad. Sci. USA, 103, 8018-8023 2006 []• Austin, C. , Battey, J. , Bradley, A. et al. : The knockout mouse project. Nat. Genet. , 36, 921-924 2004 []• Gaj, T. , Gersbach, C. 3rd. Trends Biotechnol. , 31, 397-405 2013 []• Sakuma, T. , Ochiai, H. , Kaneko, T. et al. : Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity. Sci. Rep. , 3, 3379 2013 []• Cong, L. , Ran, F. , Cox, D. et al. Science, 339, 819-823 2013 []• Mali, P. , Yang, L. , Esvelt, K. et al. : RNA-guided human genome engineering via Cas9. Science, 339, 823-826 2013 []• Wang, H. , Yang, H. , Shivalila, C. et al. Cell, 153, 910-918 2013 []• Mashiko, D. , Fujihara, Y. , Satouh, Y. et al. : Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA. Sci. Rep. , 3, 3355 2013 []• Mashiko, D. , Young, S. , Muto, M. et al. Dev. Growth Differ. , 56, 122-129 2014 []• Yin, H. , Xue, W. , Chen, S. et al. : Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nat. Biotechnol. , 32, 551-553 2014 []• Yang, H. , Wang, H. , Shivalila, C. et al. Cell, 154, 1370-1379 2013 []• Ran, F. , Hsu, P. , Lin, C. et al. : Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell, 154, 1380-1389 2013 []• Qi, L. , Larson, M. , Gilbert, L. et al. : Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell, 152, 1173-1183 2013 []• Perez-Pinera, P. , Kocak, D. , Vockley, C. et al. : RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat. Methods, 10, 973-976 2013 []• Chen, B. , Gilbert, L. , Cimini, B. et al. Cell, 155, 1479-1491 2013 []• Nishimasu, H. , Ran, F. , Hsu, P. et al. : Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell, 156, 935-949 2014 [][]• Kazuki, Y. , Hoshiya, H. , Takiguchi, M. et al. : Refined human artificial chromosome vectors for gene therapy and animal transgenesis. Gene Ther. , 18, 384-393 2011 []• Leeb, M. : Derivation of haploid embryonic stem cells from mouse embryos. Nature, 479, 131-134 2011 [] 参考図書 山本 卓 編 : 今すぐ始めるゲノム編集 実験医学別冊. 羊土社 2014 Yamamoto, T. eds. : Special Issue: Genome Editing. Dev. Growth Differ. , 56, 1-129 2014.

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モザイク

モザイク 破壊 原理

伊川 正人 (大阪大学微生物病研究所 附属感染動物実験施設) email: 領域融合レビュー, 3, e008 2014 Masahito Ikawa: Genome editing in mice opens a new era for biological and biomedical researches. Gondo, Y. , Fukumura, R. , Murata, T. et al. : ENU-based gene-driven mutagenesis in the mouse: a next-generation gene-targeting system. Exp. Anim. , 59, 537-548 2010 []• Shigeoka, T. , Kawaichi, M. : Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells. Nucleic Acids Res. , 33, e20 2005 []• Kanatsu-Shinohara, M. , Ikawa, M. , Takehashi, M. et al. : Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells. Proc. Natl. Acad. Sci. USA, 103, 8018-8023 2006 []• Austin, C. , Battey, J. , Bradley, A. et al. : The knockout mouse project. Nat. Genet. , 36, 921-924 2004 []• Gaj, T. , Gersbach, C. 3rd. Trends Biotechnol. , 31, 397-405 2013 []• Sakuma, T. , Ochiai, H. , Kaneko, T. et al. : Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity. Sci. Rep. , 3, 3379 2013 []• Cong, L. , Ran, F. , Cox, D. et al. Science, 339, 819-823 2013 []• Mali, P. , Yang, L. , Esvelt, K. et al. : RNA-guided human genome engineering via Cas9. Science, 339, 823-826 2013 []• Wang, H. , Yang, H. , Shivalila, C. et al. Cell, 153, 910-918 2013 []• Mashiko, D. , Fujihara, Y. , Satouh, Y. et al. : Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA. Sci. Rep. , 3, 3355 2013 []• Mashiko, D. , Young, S. , Muto, M. et al. Dev. Growth Differ. , 56, 122-129 2014 []• Yin, H. , Xue, W. , Chen, S. et al. : Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nat. Biotechnol. , 32, 551-553 2014 []• Yang, H. , Wang, H. , Shivalila, C. et al. Cell, 154, 1370-1379 2013 []• Ran, F. , Hsu, P. , Lin, C. et al. : Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell, 154, 1380-1389 2013 []• Qi, L. , Larson, M. , Gilbert, L. et al. : Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell, 152, 1173-1183 2013 []• Perez-Pinera, P. , Kocak, D. , Vockley, C. et al. : RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat. Methods, 10, 973-976 2013 []• Chen, B. , Gilbert, L. , Cimini, B. et al. Cell, 155, 1479-1491 2013 []• Nishimasu, H. , Ran, F. , Hsu, P. et al. : Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell, 156, 935-949 2014 [][]• Kazuki, Y. , Hoshiya, H. , Takiguchi, M. et al. : Refined human artificial chromosome vectors for gene therapy and animal transgenesis. Gene Ther. , 18, 384-393 2011 []• Leeb, M. : Derivation of haploid embryonic stem cells from mouse embryos. Nature, 479, 131-134 2011 [] 参考図書 山本 卓 編 : 今すぐ始めるゲノム編集 実験医学別冊. 羊土社 2014 Yamamoto, T. eds. : Special Issue: Genome Editing. Dev. Growth Differ. , 56, 1-129 2014.

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